Medications for the Treatment of Premature Ejaculation

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If other methods have had little effect on improving the condition then your GP can prescribe drugs to help.  There are a number of compounds found to have a beneficial effect on PE, although their effects do lessen with continued use and therefore should only be considered where all other treatments have failed.  You should also note that there are currently no drugs in the UK that have been licensed and approved for use in treating PE.  However there are drugs which exist that have been shown to have a significant impact in improving the condition, including various compounds with clinically approved statuses in other countries.  Your GP may offer to prescribe medications to you which, although officially for use in treating different disorders, have also been found to help with PE through a number of highly respected clinical trials and studies.  For example SSRIs are a group of compounds traditionally used to manage depression yet they have also been found to be of benefit to men with PE by increasing the time between sexual arousal and climax.  This is a relatively commonplace practice with a number of diseases and disorders.


Dapoxetine is an SSRI with a short lived action found to have a positive effect on men suffering from PE.  It was the first drug developed for treating PE and is, at present, the only SSRI marketed primarily for PE in men.  It is currently only approved in certain countries across Europe, in addition to South Korea and New Zealand however there are discussions in progress for its future approval in other countries.  In the UK the drug has the trade name Priligy.  SSRIs are typically prescribed as antidepressants although they have been found to have further applications to other anxiety related disorders such as PE.  Dapoxetine works by blocking the reuptake of serotonin into the presynaptic cell, thus increasing extracellular concentrations of the compounds leaving more serotonin to be available to the postsynaptic receptor.  Dapoxetine may begin to have a positive effect on your ejaculatory control even after the first dose when taken 1-3 hours before intercourse.

In addition to dapoxetine, there are additional SSRIs (sertraline, paroxetine, fluoxetine and citalopram) which have been shown to have a positive impact on IELT, though these were not originally developed for use against PE and are not yet officially licensed for such use.  Nevertheless there is merit for their use where the primary SSRI has failed to make any improvement on the condition.  However, should a second SSRI be unsuccessful in improving ejaculatory control then it is unlikely that any others will show any improvement either.

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